Publications

A coronaviral pore-replicase complex links RNA synthesis and export from double-membrane vesicles, Anan Chen, Ana-Mihaela Lupan Rui Tong Quek, Stefan G. Stanciu, Mihaela Asaftei, George A. Stanciu, Kierra S. Hardy, Taciani de Almeida Magalhães, Pamela A. Silver, Timothy J. Mitchison, and Adrian Salic, Science Advances, 2024, 10(45), eadq9580. DOI: 10.1126/sciadv.adq9580

Synthesis of Dynamic N-acylhydrazone-Based Macrocycles, Nicoleta Sandu, Anamaria Hanganu, Codruta Popescu, Alexandra Demeter, Anca Mirea, Andrei Kuncser, Cristina Tablet, Niculina Hadade, Mihaela Florea, Daniel Funeriu and Mihaela Matache, Journal of Materials Chemistry A, 2025, 13, 10232-10242. DOI: https://doi.org/10.1039/D4TA09035G

Light-Responsive Oxadiazole-Based (Hetero)aryl-azobenzenes, Bogdan C. Enache, Adela F. Simene, Anamaria Hanganu, Cristina Tablet, Augustin M. Mădălan, Codruta C. Popescu, Mihaela Matache, Synthesis-Stuttgart, 2025, 57(23), 3587-3598. DOI: 10.1055/a-2675-3787

Synthesis of Benzimidazol-2-ones by Oxidative Cyclisation Ring Closure of Amido-Urea Precursors, Maria Popescu, Anamaria Hanganu, Anca Paun, Augustin Mădălan, Catalin C. Anghel, Cristian Dobrota, Mihaela Matache, Codruta Popescu,The Journal of Organic Chemistry, 2025, 90, 44, 15555–15566. DOI: 10.1021/acs.joc.5c01551

Synthesis and investigation of novel Nickel-based Metal Organic Framework, Diandra M. Gheorghe, Anca G. Mirea, Iuliana M. Chirică, Augustin M. Mădălan, Codruta C. Popescu, Mihaela Matache, Dragoș Ciuparu, Mihaela Florea, Synthesis-Stuttgart, 2025, 57(24): 3660-3668. DOI: 10.1055/a-2720-5058

Meetings of the research team

The research team has regular weekly meetings, discussing the project progress and new literature reports, evaluating the results obtained in the lab, and planning future experiments.

Participation to scientific events

2025

Annual UB Conference for research results, 25^th-28^th of November 2025

Lipid substrates for development of alternative methods for visualization of sterols by bioorthogonal labelling.- Synthesis and characterisation, Mihai-Alexandru Molența, Anamaria Hanganu, Augustin M. Mădălan, Codruța C. Popescu, Mihaela Matache,, Adrian Șalic, poster

Synthesis of novel useful molecules for studying cellular processes, Nicoleta Sandu, A. Hanganu, Codruța C. Popescu, Mihaela Matache, Adrian Șalic, poster

Design and synthesis of novel fluorophores, Magdi El Fergani, Bogdan-C. Enache, Mihai-Alexandru Molența, Anamaria Hanganu, Codruța C. Popescu, Adrian Salic, Mihaela Matache, poster

A new class of arylazo((1,3,4-thiadiazoles) addressable with visible light, Bogdan C. Enache, Anamaria Hanganu, Codruta C. Popescu, Mihaela Matache, oral presentation

Palladium-Catalyzed Synthesis of Novel -Pyrones, Andrei G. Grecu, Maria Chirilov, Anamaria Hanganu, Codruța C. Popescu, Mihaela Matache, poster

23^rd European Symposium on Organic Chemistry (ESOC 2025), June 29^th-July 3^rd 2025, Copenhagen, Denmark

Synthesis of multifunctional chelating azides for imagining cellular processes by fast CuAAC reaction, Nicoleta Sandu,  Anamaria Hanganu, Codruta C. Popescu, Mihaela Matache, Adrian Șalic, poster

Synthesis of Novel Metal-Organic Frameworks with Application in CO₂ Capture, Diandra Gheorghe, N. Sandu, A. Hanganu, A. Mirea, M. Matache, C. Popescu, A. Păun, D. Ciuparu, poster

Multi step divergent diversity-oriented synthesis of discrete and macromolecular 1,3,4-oxadiazole congeners, Mihai-Alexandru Molența, Anamaria Hanganu, Mihaela Matache, Valentin Victor Jerca, poster

Marisiensis International Scientific Congress, 21th – 25th May 2025, Târgu Mureș, Romania

A Novel Azo-1,3,4-Oxadiazole Derivative: A Stepwise Synthesis and Photophysical Evaluation, Alexia I. Cojocaru, Bogdan C. Enache, Anamaria Hanganu, Codruța C. Popescu, Mihaela Matache, oral communication

Synthesis and Spectroscopic Analysis of Novel Fluorescent Oxadiazole Derivatives, Leah Freundlich, Cătălin Anghel, Mihaela Matache, Codruța C. Popescu, oral communication

Students Scientific Communication Symposium UniBuc – Faculty of Chemistry – 23^rd-24^th of May 2025

Our students (BSc, MSc and PhD) participated again in this annual event of the Faculty of Chemistry

Synthesis of Hydrazides and Aldehydes „Building Blocks” for Covalent Organic Frameworks Adsorbent Materials Used in Quality Air Control, Bianca-Andreea Paltin, Codruța Popescu, Mihaela Florea, Mihaela Matache, oral communication

The Synthesis of Cholesteryl Esters as Intermediates in the Transport and Storage of Cholesterol, Ciolan Tudor-Alexandru, Codruța C. Popescu, oral communication

Synthesis of tricarboxylated compounds using Suzuki-Miyaura coupling, Silvia Mato, Diandra Gheorghe, Nicoleta Sandu, Codruța Popescu, Mihaela Matache, oral communication

Polytriazole-Based Chelating Ligands for Accelerating Copper-Catalyzed ”Click” Reactions, Andrada Eremia, Anamaria Hanganu, Codruța Popescu, Anca Păun, Mihaela Matache, Adrian Șalic

Synthesis of novel materials based on N-acylhydrazone motif, Nicoleta Sandu, Mihaela Matache

Young Researchers’ International Conference on Chemistry and Chemical Engineering (YRICCCE V), 8-10^th May 2025, Cluj-Napoca, Romania

Design and synthesis of poly-functionalized azides for “click” chemistry-based microscopy applications, Nicoleta Sandu, Anamaria Hanganu, Codruța C. Popescu, Mihaela Matache, Adrian Șalic, poster

1,3,4-Oxadiazole core as Building Block for Fluorescent Materials Design, Mihai-Alexandru Molența, Anamaria Hanganu, Mihaela Matache, Valentin Victor Jerca, poster

International Conference ”Students for Students – ICSFS XXIst edition 2025, 9-13^th May 2025, Cluj-Napoca, Romania

• Poly-triazole Ligands for Accelerated copper mediated Azide-Alkyne Cycloaddition, Andrada Eremia, Anamaria Hanganu, Ioana Nicolau, Codruța Popescu, Anca Păun, Mihaela Matache, Adrian Șalic, poster
• Synthesis of copper-chelating and non-chelating azides as key intermediates for “click” reactions, Mihaela-Daniela Mușetescu, Anamaria Hanganu, Codruța Popescu, Mihaela Matache, Adrian Salic, poster
• Synthesis of Halo-Tag derived azides and their reactivity in “click” chemistry, Teodora Purice, Nicoleta Sandu, Alexandru Molența, Anamaria hanganu, Codruța Popescu, Mihaela Matache, Adrian Șalic, poster
• Synthesis of novel 1,3,5-triazine-based HaloTag probes for protein labeling. Marian-Valentin Dumitru, Anamaria Hanganu, Codruța Popescu, Mihaela Matache, Adrian Șalic, poster

“Mechanisms of intercellular communication”, Adrian Salic, invited lecture, Ryvu Therapeutics, Krakow, Poland, 4^th of April 2025

“Sending and receiving intercellular signals”, Adrian Salic, invited lecture, Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland, 3^rd of April 2025

“How cells talk to each other”, Adrian Salic, invited lecture, ISIS, University of Strasbourg, France, 14^th of March 2025

“Mechanisms of intercellular communication”, Adrian Salic, invited lecture, IBMC, University of Strasbourg, 11^th of January 2025

2024

• “Sending and receiving intercellular signals”, Fédération de Médicine Translationnelle de Strasbourg, France 4^th of December 2024

Third edition of the annual conference for communication of research results at the University of Bucharest, 25th-29th of November, Bucharest, Romania

Organic synthesis – from training to research of the next organic synthesists generation, Mihaela Matache, Codruța Popescu, Anca Păun, Ioana Nicolau, Anamaria Hanganu, Daniel P. Funeriu, Adrian Șalic, oral presentation

Chemistry Day – 16th of October 2024, Bucharest, Romania- event organized within SciResCareer

Synthesis of 1,3,4-oxadiazole-decorated azobenzenes – from fluorophores to molecular photoswitches, Adela Dobre, oral presentation

N-acylhydrazone – fundamental building block for development of new materials by dynamic combinatorial chemistry, Nicoleta Sandu, oral presentation

The Annual International Conference of the RSBMB, 25th-27th of September, Bucharest, Romania

Sending and receiving intracellular signals, Adrian Salic, plenary lecture

New Trends in Chemistry Research 2024, 18th-20th of September, Timișoara, Romania

Synthesis of amino azides as building blocks for “click”-based cellular imaging probes, Nicoleta Sandu, Mihaela D. Mușetescu, Anamaria Hanganu, Codruța C. Popescu, Mihaela Matache, Adrian Șalic, poster

Novel halo-tag probes for cellular imaging applications, Teodora Purice, Adela Dobre, Anamaria Hanganu, Codruța Popescu, Mihaela Matache, Adrian Șalic, poster

Synthesis of triazole heterocyclic intermediates and ligands for ”click” chemistry, Andrada Eremia, Anamaria Hanganu, Ioana Nicolau, Codruța Popescu, Anca Păun, Mihaela Matache, Adrian Șalic, poster

New synthetic strategy for the synthesis of heterocyclic compounds mediated by hypervalent iodine agents, Maria Popescu, Mihaela Matache, Augustin Madalan, Anamaria Hanganu, Anca Paun, Ioana Nicolau, Codruța Popescu, oral presentation

Synthetic approaches of photo-sensitive azo-based switching probes, Mihaela Matache, plenary lecture

17^th European Biological Inorganic Chemistry Conference (EuroBIC-17)

Multidentate organic ligands in design of supramolecular protein oligomerization platforms, Ioana Nicolau, Mihaela Matache, Niculina Hadade, Alexandra Bumbacaru, Daniel P. Funeriu, poster

9^th EuChemS Chemistry Congress (ECC9), Dublin, Ireland, 7^th – 11^th July, 2024

N-acylhydrazone – fundamental building block for development of new materials by dynamic combinatorial chemistry, Nicoleta Sandu, Alexia Cojocaru, Teodora Purice, Anca Mirea, Anamaria Hanganu, Anca Păun, Codruța Popescu, Mihaela Matache, poster

Synthesis of novel N-donor linkers for metal-organic frameworks with application in CO₂ capture, Diandra Gheorghe, Nicoleta Sandu, Anamaria Hanganu, Anca Mirea, Mihaela Matache, Codruța Popescu, Anca Păun, Dragoș Ciuparu

Synthetic approaches of photo-sensitive azo switches, Adela Dobre, Bogdan C. Enache, Nicoleta Sandu, Anamaria Hanganu, Codruța C. Popescu, Anca Paun, Ioana Nicolau, Mihaela Matache, oral presentation

Synthesis of novel benzimidazole-2-ones mediated by hypervalent iodine agent, Maria Popescu, Mihaela Matache, Augustin Madalan, Anamaria Hanganu, Anca Păun, Ioana Nicolau, Codruța Popescu, oral presentation

Students Scientific Communication Symposium UniBuc – Faculty of Chemistry – 24^th-25^th of May 2024

Our students (BSc, MSc and PhD) actively participated to the event, with presentation of their work in the lab, preparing for the finalizing exams.

Synthesis of Boc-protected azides – key intermediates for “click” chemistry applications, Mihaela-Daniela Mușetescu, Nicoleta Sandu, Codruța Popescu, Mihaela Matache, Adrian Salic

Multidentate Organic Ligands in Design of Molecular Protein Oligomerization Platforms, Alexandra Bumbăcaru, Ioana Nicolau, Anamaria Hanganu, Mihaela Matache, Daniel P. Funeriu

First steps in developing 1,3,4-oxadizoles based fluorescent hydrogels, Mihai-Alexandru Molenta, Mihaela Matache, Victor Jerca

Synthesis and Characterization of Bioactive Compounds Containing an α-Pyrone Structural Motif, Andrei-Gabriel Grecu, Adela-Florentina Dobre, Anamaria Hanganu, Codruța Popescu, Mihaela Matache

Symposium „Modern Directions in Materials Chemistry“ – Romania Academy – 7th of June 2024

Dr. Mihaela Matache participated with a presentation within the symposium that hosted guests from MIT and Princeton University.

Synthetic approaches of photo-sensitive azo switches

Contributions to PhD, MSc and PhD thesis

Andrada Irina Eremia – MSc 2025 – Poly-triazole ligands for accelerated “click” reactions

Teodora Chrstina Purice – MSc 2025 -Synthesis, spectroscopic characterization, and theoretical study of key intermediates in lipid visualization

Alexandra Bumbacaru – MSc 2024 -Multidentate organic ligands for the design of protein oligomerization platforms